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Women Taking Phentermine

Obesity is the most common nutritional abnormality in the United States and much of the world. According to the National Health and Nutrition Examination Survey (NHANES), 22.5% of the US population are obese (body mass index [BMI] ³30 kg/m2) and 55% are overweight (BMI ³25 kg/m2).1,2 These data represent an increase in the prevalence of obesity of more than 50% since 1980. Obesity produces numerous comorbidities, such as diabetes mellitus, hypertension, dyslipidemia, sleep apnea, cancer, and gall bladder disease, all of which contribute to the increase in mortality with obesity, particularly in younger individuals.3-6 It has been estimated that obesity contributes to approximately 300,000 deaths annually among adults in the US.7

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Obesity is associated with several comorbid health conditions. Although diet modification and exercise are extremely important for long-term weight maintenance and overall health, some obese patients need and benefit from the inclusion of pharmacotherapy.

However, the new generation of antiobesity drugs offer physicians new treatment strategies for their patients relatively safely, effectively, and responsibly. In this review, we discuss the pharmacologic treatment of obesity, including a discussion of recently approved drugs as well as those previously approved and still available.

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